"Neural Crest Migration and Possible Implications in Cancer Metastasis"
Shuyi Nie, Ph.D.
School of Biological Sciences
The neural crest is a unique population of cells in vertebrate. Induced at the neural plate border, neural crest cells detach from the neuroepithelium and migrate extensively to different parts of the embryo and give rise to multiple tissue and organs including neurons and glia, bones and cartilage, and pigment cells. Both the behavior of neural crest cells and signaling molecules in neural crest development are similar to that of metastatic cancer. In fact, dysregulation of neural crest development results in multiple cancer, including neuroblastoma, glioblastoma, and melanoma. Through studying the molecular and cellular mechanisms of neural crest cell EMT and migration, we hope to gain insights into cancer metastasis.
Georgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics.