Prof. Shuichi Takayama
Wallace H. Coulter Department of Biomedical Engineering
Georgia Tech and Emory University
Abstract: This presentation will give an overview of efforts in our laboratory to develop microfluidic systems to control cell microenvironments and to perform high precision biochemical measurements. Microfluidic technologies to be discussed include computer-controlled microfluidics, self-switching microfluidic transistor-like circuitry, microfluidics that utilize aqueous two phase droplets, and fracture fabrication of tunable nanochannels. Specific biomedical applications that will be discussed include lung-on-a-chip, microfluidic assisted reproductive technologies and in vitro fertilization, heartbeat-on-a-chip, chromatin analysis in fracture-fabricated nanochannels, and protein biomarker analysis. The long-term goal is to create miniature patients-on-a-chip for understanding disease mechanisms, testing drugs, performing better cell-based therapies, and validating protein biomarkers.
Bio: Prof. Shuichi Takayama’s research interests (B.S. & M.S. from the University of Tokyo, Ph.D. from the Scripps Research Institute) started with organic synthesis of enzyme inhibitors. Subsequently he pursued postdoctoral studies in bioengineered microsystems at Harvard University as a Leukemia and Lymphoma Society Fellow with goal of developing microsystems to perform bioevaluations of the inhibitor molecules he synthesized. He spent 17 years at the University of Michigan in the Biomedical Engineering Department and Macromolecular Science and Engineering Program then moved to the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory School of Medicine in the summer of 2017. He is an associate editor of Integrative Biology and on the board of several other journals. Awards and honors include the NSF CAREER award, Pioneers of Miniaturization Prize, and AIMBE Fellow.